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active metabolite
An active metabolite is an active form of a drug after it has been processed by the body.
== Metabolites of drugs ==
An active metabolite results when a drug is metabolized by the body into a modified form which continues to produce effects in the body. Usually these effects are similar to those of the parent drug but weaker, although they can still be significant (see e.g. 11-hydroxy-THC, morphine-6-glucuronide). Certain drugs such as codeine and tramadol have metabolites that are stronger than the parent drug (morphine and ''O''-desmethyltramadol respectively) and in these cases the metabolite may be responsible for much of the therapeutic action of the parent drug. Sometimes, however, metabolites may produce toxic effects and patients must be monitored carefully to ensure they do not build up in the body. This is an issue with some well known drugs such as pethidine (meperidine) and dextropropoxyphene.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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